Bile Acid Salt as a Vehicle for Solubilization and Electrodeposition of Drugs and Functional Biomolecules for Surface Modification of Materials

This investigation addresses the need in biocompatible biosurfactants for electrophoretic deposition (EPD) of biomaterials. It is motivated by unique multifunctional properties bile acid salts. Sodium cholate CHOLNa a primary salt, which can solubilize and disperse different functional The EPD mechanism pure involves electrophoresis (EP) CHOL− micelles, their discharge gelation cholic (CHOLH) to form anodic CHOLH films. strategy immobilization biomolecules based on formation EP mixed micelles. Curcumin(CCM), hydrocortisone (HCS), indomethacin (IDM) are used as model electrically neutral water insoluble drugs composite acts solubilizing agent, forms micelles with pH-dependent charge various reversal at isoelectric points prevents deposition. problem addressed use co-deposition bovine serum albumin (BSA) hemoglobin (Hb), proteins CHOLH-BSA CHOLH-Hb Another challenge related pH-independent charge, such heparin (HP). feasibility CHOLH-HP films demonstrated. mechanisms, film composition, morphologies discussed. approach developed this offers advantages charging gel-forming agents mild conditions fabrication drug delivery, biosensors, surface modification biomedical implants.